How Does ACE-031 Work

Myostatin Inhibition:

• Myostatin is a protein that inhibits muscle differentiation and growth.

• ACE-031 acts as a "decoy receptor"—it binds circulating myostatin, preventing it from interacting with muscle cell receptors.

• This releases the “brakes” on muscle growth, allowing for increased muscle mass and strength.

ACE-031 also binds activins A and B, which are involved in inflammation and muscle

catabolism, enhancing its muscle-preserving effects.

Why Use ACE-031?

Originally developed to treat muscle-wasting diseases, especially:

• Duchenne muscular dystrophy (DMD)

• Sarcopenia (age-related muscle loss)

• Cachexia (muscle wasting due to cancer, AIDS, chronic illness)

• Spinal muscular atrophy (SMA)

• COPD-related muscle atrophy

Potential Uses (Off-Label/Experimental):

• Athletic performance and bodybuilding (muscle hypertrophy)

• Faster recovery from injury or surgery

• Preventing muscle loss during cutting or illness

Reported Effects:

From animal studies and early human trials (before trials were halted):

• Increase in lean muscle mass

• Enhanced strength and endurance

• Reduced fat mass

• No significant androgenic effects (unlike most anabolic steroids)

• Results were rapid—muscle gain in weeks, not months, was observed in trials